COVAXIN, is an inactivated, virus-based Covid-19 vaccine developed by Bharat Biotech, in collaboration with the Indian Council of Medical Research.
Bharat Biotech is a 24-year old vaccine maker with a portfolio of 16 vaccines and exports to 123 countries.
A Vaccine Made from Coronaviruses
COVAXIN works by teaching the immune system to make antibodies against the SARS-CoV-2 coronavirus. The antibodies attach to viral proteins, such as the so-called spike proteins that stud its surface.
To create Covaxin, Bharat Biotech used a sample of the coronavirus isolated by India's National Institute of Virology.
KILLING THE VIRUS
Once the researchers produced large stocks of the coronaviruses, they doused them with a chemical called beta-propiolactone. The compound disabled the coronaviruses by bonding to their genes. The inactivated coronaviruses could no longer replicate, but their proteins, including spike, remained intact. The inactivated viruses is then mixed with a tiny amount of aluminium-based compound called an adjuvant. Adjuvants stimulate the immune system to boost its response to a vaccine.
"COVAXIN" has demonstrated an excellent safety record in human clinical trials and in vaccine administration under emergency use in India. Our goal for all vaccines developed by Bharat Biotech is to provide global access. With its potential effectiveness against multiple existing and emerging variants, we belive that COVAXIN is an important vaccine for everyone, including children, based on its unique yet traditional vaccine platform."
Bharat Biotech chairman and managing director, Dr Krishna Ella
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